Published Work
Estrogen and testosterone supplementation improves tendon healing and functional recovery after rotator cuff repair. Tashjian RZ, Zitnay J, Kazmers NH, Veerabhadraiah SR, Zelada AC, Honeggar M, Chalmers PN, Henninger HB, Jurynec MJ. J Orthop Res. 2024 Feb;42(2):259-266. doi: 10.1002/jor.25695. Epub 2023 Oct 8.
ORS Tendon Section - Tendon Section Membership Committee Pick
Meta-analysis identifies sequence variants in ALDH1A2, MGP, SPP1 and BMP6 associated with erosive hand osteoarthritis. Styrkarsdottir U, Stefansdottir L, Thorleifsson G, Stefansson OA, Lund SH, Rafnar T, Hoshijima K, Novak KA, Oreiro-Villar N, Rego-Perez I, Hansen C, Kazmers NH, Kiemeney LA, Blanco FJ, Barker T, Kloppenburg M, Jurynec MJ, Gudjartsson DF, Jonsson H, Thorsteinsdottir U, Stefansson K. Ann Rheum Dis. 2023 Mar 17:ard-2022-223468. doi: 10.1136/ard-2022-223468.
Familial Clustering and Genetic Analysis of Severe Thumb Carpometacarpal Joint Osteoarthritis in a Large Statewide Cohort. Gavile CM, Kazmers NH, Novak KA, Meeks HD, Yu Z, Thomas JL, Barker T, Jurynec MJ. J Hand Surg Am. 2022 Sep 2;S0363-5023(22)00458-0. doi:10.1016/j.jhsa.2022.08.004. Online ahead of print.
Editor's Choice Article and Podcast Interview
Summary Report of the Arthritis Foundation and the American Orthopaedic Foot & Ankle Society's Symposium on Targets for Osteoarthritis Research: Part 1: Epidemiology, Pathophysiology, and Current Imaging Approaches. Kim J, Amendola A, Baumhauer J, Brodsky JW, Cushman DM, Gonzalez TA, Janisse D, Jurynec MJ, Marsh JM, Sofka CM, Clanton TO, Anderson DD. Foot Ankle Orthop. 2022 Oct 5; 7(4):24730114221127011. doi: 10.1177/24730114221127011. eCollection 2022 Oct.
Summary Report of the Arthritis Foundation and the American Orthopaedic Foot & Ankle Society's Symposium on Targets for Osteoarthritis Research: Part 2: Treatment Options. Kim J, Amendola A, Baumhauer J, Brodsky JW, Cushman DM, Gonzalez TA, Janisse D, Jurynec MJ, Marsh JM, Sofka CM, Clanton TO, Anderson DD. Foot Ankle Orthop. 2022 Oct 14; 7(4):24730114221127013. doi:10.1177/24730114221127013. eCollection 2022 Oct.
Current Cellular and Molecular Biology Techniques for the Orthopaedic Surgeon-Scientist. Davies M, Jurynec MJ, Gomez-Alvarado F, Hu D, Feeley SE, Allen-Brady K, Tashjian RZ, Feeley BT. Journal of Shoulder and Elbow Surgery. Online August 18, 2022.
The NOD/RIPK2 signaling pathway contributes to osteoarthritis susceptibility. Jurynec MJ, Gavile CM, Honeggar M, Ma Y, Veerabhadraiah SR, Novak KA, Hoshijima K, Kazmers NH, Grunwald DJ. Ann Rheum Dis. 2022 Jun 22;annrheumdis-2022-222497. doi: 10.1136/annrheumdis-2022-222497. Online ahead of print
Supraspinatus Rotator Cuff Repair: A mouse model and technique. Miller M, Kazmers NH, Chalmers PN, Tashjian RZ, Jurynec MJ. Arthrosc Tech. 2021 Jul 13;10(8):e1949-e1954. doi: 10.1016/j.eats.2021.04.023. eCollection 2021 Aug.
The Effect of Estrogen-Like Compound on Rotator Cuff Tendon Healing in a Murine Model.
Tashjian RZ, Kazmers NH, Epperson RT, Honeggar M, Ma Y, Chalmers PN, Williams DL, Jurynec MJ.
J Orthop Res. 2021 Feb 2. doi: 10.1002/jor.25000. Online ahead of print. PMID: 33533088
A role for the MEGF6 gene in predisposition to osteoporosis.
Teerlink CC*, Jurynec MJ*, Hernandez R, Stevens J, Hughes DC, Brunker CP, Rowe K, Grunwald DJ, Facelli JC, Cannon-Albright LA.
Ann Hum Genet. 2020 Oct 7. doi: 10.1111/ahg.12408. Online ahead of print. PMID: 33026655. *- co-first authors
Familial clustering of erosive hand osteoarthritis in a large statewide cohort.
Kazmers NH, Meeks HD, Novak KA, Yu Z, Fulde GL, Thomas JL, Barker T, Jurynec MJ
Arthritis Rheumatol. 2020 Sep 17. doi: 10.1002/art.41520. Online ahead of print. PMID: 32940959
A&R Journal Club selection
RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells.
Santoriello C, Sporrij A, Yang S, Flynn RA, Henriques T, Dorjsuren B, Custo Greig E, McCall W, Stanhope ME, Fazio M, Superdock M, Lichtig A, Adatto I, Abraham BJ, Kalocsay M, Jurynec M, Zhou Y, Adelman K, Calo E, Zon LI.
Nat Cell Biol. 2020 Apr;22(4):372-379. doi: 10.1038/s41556-020-0493-0. Epub 2020 Mar 30. PMID: 32231306
Jurynec MJ, Bai X, Bisgrove BW, Jackson H, Nechiporuk A, Palu RAS, Grunwald HA, Su YC, Hoshijima K, Yost HJ, Zon LI, Grunwald DJ.
Development. 2019 Nov 29. pii: dev.180133. doi: 10.1242/dev.180133. [Epub ahead of print}. PMID: 31784460
Evaluation for Kienböck Disease Familial Clustering: A Population-Based Cohort Study.
Kazmers NH, Yu Z, Barker T, Abraham T, Romero R, Jurynec MJ.
J Hand Surg Am. 2019 Nov 21. pii: S0363-5023(19)31415-7. doi: 10.1016/j.jhsa.2019.10.005. [Epub ahead of print]. PMID: 31761504
Editor's Choice Article
Hoshijima K, Jurynec MJ, Klatt Shaw D, Jacobi AM, Behlke MA, Grunwald DJ.
Dev Cell. 2019 Dec 2;51(5):645-657.e4. doi: 10.1016/j.devcel.2019.10.004. Epub 2019 Nov 7. PMID: 31708433
A hyperactivating proinflammatory RIPK2 allele associated with early-onset osteoarthritis.
Jurynec MJ, Sawitzke AD, Beals TC, Redd MJ, Stevens J, Otterud B, Leppert MF, Grunwald DJ.
Hum Mol Genet. 2018 Jul 1;27(13):2406. doi: 10.1093/hmg/ddy196. PMID: 29860498
Intracellular Calcium Mobilization Is Required for Sonic Hedgehog Signaling.
Klatt Shaw D, Gunther D, Jurynec MJ, Chagovetz AA, Ritchie E, Grunwald DJ.
Dev Cell. 2018 May 21;45(4):512-525.e5. doi: 10.1016/j.devcel.2018.04.013. Epub 2018 May 10. PMID: 29754802
A hyperactivating proinflammatory RIPK2 allele associated with early-onset osteoarthritis.
Jurynec MJ, Sawitzke AD, Beals TC, Redd MJ, Stevens J, Otterud B, Leppert MF, Grunwald DJ.
Hum Mol Genet. 2018 Jul 1;27(13):2383-2391. doi: 10.1093/hmg/ddy132. PMID: 29659823
Precise genome editing by homologous recombination.
Hoshijima K, Jurynec MJ, Grunwald DJ.
Methods Cell Biol. 2016;135:121-47. doi: 10.1016/bs.mcb.2016.04.008. Epub 2016 May 2. PMID: 27443923
Precise Editing of the Zebrafish Genome Made Simple and Efficient.
Hoshijima K, Jurynec MJ, Grunwald DJ.
Dev Cell. 2016 Mar 21;36(6):654-67. doi: 10.1016/j.devcel.2016.02.015. PMID: 27003937
Dahlem TJ, Hoshijima K, Jurynec MJ, Gunther D, Starker CG, Locke AS, Weis AM, Voytas DF, Grunwald DJ.
PLoS Genet. 2012;8(8):e1002861. doi: 10.1371/journal.pgen.1002861. Epub 2012 Aug 16. PMID: 22916025
Wythe JD, Jurynec MJ, Urness LD, Jones CA, Sabeh MK, Werdich AA, Sato M, Yost HJ, Grunwald DJ, Macrae CA, Li DY.
Dis Model Mech. 2011 Sep;4(5):607-21. doi: 10.1242/dmm.002204. Epub 2011 May 31. PMID: 21628396
Jurynec MJ, Grunwald DJ.
Dis Model Mech. 2010 Nov-Dec;3(11-12):733-42. doi: 10.1242/dmm.000703. Epub 2010 Jul 8. PMID: 20616095
TIF1gamma controls erythroid cell fate by regulating transcription elongation.
Bai X, Kim J, Yang Z, Jurynec MJ, Akie TE, Lee J, LeBlanc J, Sessa A, Jiang H, DiBiase A, Zhou Y, Grunwald DJ, Lin S, Cantor AB, Orkin SH, Zon LI.
Cell. 2010 Jul 9;142(1):133-43. doi: 10.1016/j.cell.2010.05.028. PMID: 20603019
Jurynec MJ, Xia R, Mackrill JJ, Gunther D, Crawford T, Flanigan KM, Abramson JJ, Howard MT, Grunwald DJ.
Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12485-90. doi: 10.1073/pnas.0806015105. Epub 2008 Aug 19.
PMID: 18713863
SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans.
Lamason RL, Mohideen MA, Mest JR, Wong AC, Norton HL, Aros MC, Jurynec MJ, Mao X, Humphreville VR, Humbert JE, Sinha S, Moore JL, Jagadeeswaran P, Zhao W, Ning G, Makalowska I, McKeigue PM, O'donnell D, Kittles R, Parra EJ, Mangini NJ, Grunwald DJ, Shriver MD, Canfield VA, Cheng KC.
Science. 2005 Dec 16;310(5755):1782-6. PMID: 16357253
Two divergent slit1 genes in zebrafish.
Hutson LD, Jurynec MJ, Yeo SY, Okamoto H, Chien CB.
Dev Dyn. 2003 Nov;228(3):358-69. PMID: 14579375
Jurynec MJ, Riley CP, Gupta DK, Nguyen TD, McKeon RJ, Buck CR.
Mol Cell Neurosci. 2003 May;23(1):69-80. PMID: 12799138
Increased adenine nucleotide translocator 1 in reactive astrocytes facilitates glutamate transport.
Buck CR, Jurynec MJ, Gupta DK, Law AK, Bilger J, Wallace DC, McKeon RJ.
Exp Neurol. 2003 Jun;181(2):149-58. PMID: 12781988
McKeon RJ, Jurynec MJ, Buck CR.
J Neurosci. 1999 Dec 15;19(24):10778-88. PMID: 10594061