Published Work

The NOD/RIPK2 signaling pathway contributes to osteoarthritis susceptibility. Jurynec MJ, Gavile CM, Honeggar M, Ma Y, Veerabhadraiah SR, Novak KA, Hoshijima K, Kazmers NH, Grunwald DJ. bioRxiv. 2022 February; 2022.02.07.479420. doi: 10.1101/2022.02.07.479420.

Familial Clustering and Genetic Analysis of Severe Thumb Carpometacarpal Joint Osteoarthritis in a Large Statewide Cohort. Gavile CM, Kazmers NH, Novak KA, Meeks HD, Yu Z, Thomas JL, Barker T, Jurynec MJ. medRxiv. 2022 March; :2022.03.03.22271851. doi: 10.1101/2022.03.03.22271851.

Supraspinatus Rotator Cuff Repair: A mouse model and technique. Miller M, Kazmers NH, Chalmers PN, Tashjian RZ, Jurynec MJ. Arthroscopy. 2021. In Press

The Effect of Estrogen-Like Compound on Rotator Cuff Tendon Healing in a Murine Model.

Tashjian RZ, Kazmers NH, Epperson RT, Honeggar M, Ma Y, Chalmers PN, Williams DL, Jurynec MJ.
J Orthop Res. 2021 Feb 2. doi: 10.1002/jor.25000. Online ahead of print. PMID: 33533088

A role for the MEGF6 gene in predisposition to osteoporosis.

Teerlink CC*, Jurynec MJ*, Hernandez R, Stevens J, Hughes DC, Brunker CP, Rowe K, Grunwald DJ, Facelli JC, Cannon-Albright LA.

Ann Hum Genet. 2020 Oct 7. doi: 10.1111/ahg.12408. Online ahead of print. PMID: 33026655. *- co-first authors

Familial clustering of erosive hand osteoarthritis in a large statewide cohort.
Kazmers NH, Meeks HD, Novak KA, Yu Z, Fulde GL, Thomas JL, Barker T, Jurynec MJ

Arthritis Rheumatol. 2020 Sep 17. doi: 10.1002/art.41520. Online ahead of print. PMID: 32940959 - *A&R Journal Club selection

RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells.

Santoriello C, Sporrij A, Yang S, Flynn RA, Henriques T, Dorjsuren B, Custo Greig E, McCall W, Stanhope ME, Fazio M, Superdock M, Lichtig A, Adatto I, Abraham BJ, Kalocsay M, Jurynec M, Zhou Y, Adelman K, Calo E, Zon LI.

Nat Cell Biol. 2020 Apr;22(4):372-379. doi: 10.1038/s41556-020-0493-0. Epub 2020 Mar 30. PMID: 32231306


The Paf1 Complex and P-TEFb have reciprocal and antagonist roles in maintaining multipotent neural crest progenitors.

Jurynec MJ, Bai X, Bisgrove BW, Jackson H, Nechiporuk A, Palu RAS, Grunwald HA, Su YC, Hoshijima K, Yost HJ, Zon LI, Grunwald DJ.

Development. 2019 Nov 29. pii: dev.180133. doi: 10.1242/dev.180133. [Epub ahead of print}. PMID: 31784460

*Research Highlight


Evaluation for Kienböck Disease Familial Clustering: A Population-Based Cohort Study.

Kazmers NH, Yu Z, Barker T, Abraham T, Romero R, Jurynec MJ.

J Hand Surg Am. 2019 Nov 21. pii: S0363-5023(19)31415-7. doi: 10.1016/j.jhsa.2019.10.005. [Epub ahead of print]. PMID: 31761504

*Editor's Choice Article

Highly Efficient CRISPR-Cas9-Based Methods for Generating Deletion Mutations and F0 Embryos that Lack Gene Function in Zebrafish.

Hoshijima K, Jurynec MJ, Klatt Shaw D, Jacobi AM, Behlke MA, Grunwald DJ.

Dev Cell. 2019 Dec 2;51(5):645-657.e4. doi: 10.1016/j.devcel.2019.10.004. Epub 2019 Nov 7. PMID: 31708433

A hyperactivating proinflammatory RIPK2 allele associated with early-onset osteoarthritis.

Jurynec MJ, Sawitzke AD, Beals TC, Redd MJ, Stevens J, Otterud B, Leppert MF, Grunwald DJ.

Hum Mol Genet. 2018 Jul 1;27(13):2406. doi: 10.1093/hmg/ddy196. PMID: 29860498

Intracellular Calcium Mobilization Is Required for Sonic Hedgehog Signaling.

Klatt Shaw D, Gunther D, Jurynec MJ, Chagovetz AA, Ritchie E, Grunwald DJ.

Dev Cell. 2018 May 21;45(4):512-525.e5. doi: 10.1016/j.devcel.2018.04.013. Epub 2018 May 10. PMID: 29754802

A hyperactivating proinflammatory RIPK2 allele associated with early-onset osteoarthritis.

Jurynec MJ, Sawitzke AD, Beals TC, Redd MJ, Stevens J, Otterud B, Leppert MF, Grunwald DJ.

Hum Mol Genet. 2018 Jul 1;27(13):2383-2391. doi: 10.1093/hmg/ddy132. PMID: 29659823

Precise genome editing by homologous recombination.

Hoshijima K, Jurynec MJ, Grunwald DJ.

Methods Cell Biol. 2016;135:121-47. doi: 10.1016/bs.mcb.2016.04.008. Epub 2016 May 2. PMID: 27443923

Precise Editing of the Zebrafish Genome Made Simple and Efficient.

Hoshijima K, Jurynec MJ, Grunwald DJ. 

Dev Cell. 2016 Mar 21;36(6):654-67. doi: 10.1016/j.devcel.2016.02.015. PMID: 27003937


Simple methods for generating and detecting locus-specific mutations induced with TALENs in the zebrafish genome.

Dahlem TJ, Hoshijima K, Jurynec MJ, Gunther D, Starker CG, Locke AS, Weis AM, Voytas DF, Grunwald DJ.

PLoS Genet. 2012;8(8):e1002861. doi: 10.1371/journal.pgen.1002861. Epub 2012 Aug 16. PMID: 22916025


Hadp1, a newly identified pleckstrin homology domain protein, is required for cardiac contractility in zebrafish.

Wythe JD, Jurynec MJ, Urness LD, Jones CA, Sabeh MK, Werdich AA, Sato M, Yost HJ, Grunwald DJ, Macrae CA, Li DY.

Dis Model Mech. 2011 Sep;4(5):607-21. doi: 10.1242/dmm.002204. Epub 2011 May 31. PMID: 21628396


SHIP2, a factor associated with diet-induced obesity and insulin sensitivity, attenuates FGF signaling in vivo.

Jurynec MJ, Grunwald DJ.

Dis Model Mech. 2010 Nov-Dec;3(11-12):733-42. doi: 10.1242/dmm.000703. Epub 2010 Jul 8. PMID: 20616095


TIF1gamma controls erythroid cell fate by regulating transcription elongation.

Bai X, Kim J, Yang Z, Jurynec MJ, Akie TE, Lee J, LeBlanc J, Sessa A, Jiang H, DiBiase A, Zhou Y, Grunwald DJ, Lin S, Cantor AB, Orkin SH, Zon LI.

Cell. 2010 Jul 9;142(1):133-43. doi: 10.1016/j.cell.2010.05.028. PMID: 20603019


Selenoprotein N is required for ryanodine receptor calcium release channel activity in human and zebrafish muscle.

Jurynec MJ, Xia R, Mackrill JJ, Gunther D, Crawford T, Flanigan KM, Abramson JJ, Howard MT, Grunwald DJ.

Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12485-90. doi: 10.1073/pnas.0806015105. Epub 2008 Aug 19.

PMID: 18713863


SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans.

Lamason RL, Mohideen MA, Mest JR, Wong AC, Norton HL, Aros MC, Jurynec MJ, Mao X, Humphreville VR, Humbert JE, Sinha S, Moore JL, Jagadeeswaran P, Zhao W, Ning G, Makalowska I, McKeigue PM, O'donnell D, Kittles R, Parra EJ, Mangini NJ, Grunwald DJ, Shriver MD, Canfield VA, Cheng KC.

Science. 2005 Dec 16;310(5755):1782-6. PMID: 16357253 


Two divergent slit1 genes in zebrafish.

Hutson LD, Jurynec MJ, Yeo SY, Okamoto H, Chien CB.

Dev Dyn. 2003 Nov;228(3):358-69. PMID: 14579375


TIGR is upregulated in the chronic glial scar in response to central nervous system injury and inhibits neurite outgrowth.

Jurynec MJ, Riley CP, Gupta DK, Nguyen TD, McKeon RJ, Buck CR.

Mol Cell Neurosci. 2003 May;23(1):69-80. PMID: 12799138

Increased adenine nucleotide translocator 1 in reactive astrocytes facilitates glutamate transport.

Buck CR, Jurynec MJ, Gupta DK, Law AK, Bilger J, Wallace DC, McKeon RJ.

Exp Neurol. 2003 Jun;181(2):149-58. PMID: 12781988


The chondroitin sulfate proteoglycans neurocan and phosphacan are expressed by reactive astrocytes in the chronic CNS glial scar.

McKeon RJ, Jurynec MJ, Buck CR. 

J Neurosci. 1999 Dec 15;19(24):10778-88. PMID: 10594061